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thesciencellama:

HIV antibodies neutralize 88% of worldwide HIV types & 2/3 of subtype C

A unique change in the outer covering of the virus allowed for antibodies to attach and neutralize 88% if HIV types around the world. This is known as a broadly neutralizing antibody response and was due to the body pressuring the virus to change its surface coating to have a sugar (glycan) ‘tag’ in the 332 position which then allowed the immune systems antibodies to attack it.

According to Professor Salim Abdool Karim, president of the Medical Research Council, “Broadly neutralizing antibodies are considered to be the key to making an AIDS vaccine. This discovery provides new clues on how vaccines could be designed to elicit broadly neutralizing antibodies.”

Though, because the weak point at position 332 is only in ~70% of the subtype C viruses (the subtype most common in Africa), antibodies will need to be developed that can target more glycans on the virus.

Photo 1 is structure of HIV
Photo 2 is of HIV budding from a cell 

Via nature.com in the article “Evolution of an HIV glycan-dependent broadly neutralizing antibody epitope through immune escape”

(Source: the-science-llama)

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93 notes &

laboratoryequipment: Nanofilm Prevents Premature Implant FailuresEvery year, more than a million Americans receive an artificial hip or knee prosthesis. Such implants are designed to last many years, but in about 17 percent of patients who receive a total joint replacement, the implant eventually loosens and has to be replaced early, which can cause dangerous complications for elderly patients.To help minimize these burdensome operations, a team of MIT chemical engineers has developed a new coating for implants that could help them better adhere to the patient’s bone, preventing premature failure.Read more: http://www.laboratoryequipment.com/news-Nanofilm-Could-Prevent-Hip-Implant-Failures-042012.aspx

laboratoryequipment:

Nanofilm Prevents Premature Implant Failures

Every year, more than a million Americans receive an artificial hip or knee prosthesis. Such implants are designed to last many years, but in about 17 percent of patients who receive a total joint replacement, the implant eventually loosens and has to be replaced early, which can cause dangerous complications for elderly patients.

To help minimize these burdensome operations, a team of MIT chemical engineers has developed a new coating for implants that could help them better adhere to the patient’s bone, preventing premature failure.

Read more: http://www.laboratoryequipment.com/news-Nanofilm-Could-Prevent-Hip-Implant-Failures-042012.aspx

Filed under science